Multiple theories have been put forth that explains the pathological disorganization in the collagen fibers of the Anterior Cruciate Ligament, such as synovial, traumatic, and degenerative, "Synovial theory- states that there is accumulation of synovial fluid inside the substance of ACL in a herniated pouch of synovium. Exclusion criteria were (1) case reports, literature reviews and conference abstracts and (2) studies written in languages other than English. AJR Am J Roentgenol. Mucoid Degeneration of the Anterior Cruciate Ligament: A Case Report Reduction plasty for hypertrophic anterior cruciate ligament mucoid degeneration: clinical and knee laxity outcomes in 23 cases. Each study was scored 02 on each question, with a global ideal score of 16. Bilateral Symptomatic Mucoid Degeneration of the Anterior - Hindawi PDF Mucoid degenerated anterior cruciate ligament managed by arthroscopic To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. 2 ). Another theory is the synovial theory whereby a pouch of synovium herniates and is subsequently filled with synovium [2]. Coronal T2 weighted fat suppressed fast spin echo image showed complex anterior cruciate ligament ganglion cyst arising from superior aspect of ligament. Anterior Cruciate Ligament (ACL) MRI: Practice Essentials, Anatomy in 1999 [1]. PROSPERO. Magn Reson Imaging Clin N Am. Mucoid degeneration of the ACL is suspected when an apparently thickened and ill-defined ligament with increased signal intensity on all sequences in MRI is identified in a patient with physically intact ligament and no obvious trauma history. National Library of Medicine [Diagnosis and treatment of anterior cruciate ligament cysts]. The review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines and registered in the PROSPERO database (CRD42018087782). Before Epub 2010 May 8. Results: PubMedGoogle Scholar. Unlike meniscal tears and chondral defects, the mucoid degeneration of the anterior cruciate ligament (ACL) is a rare cause of knee pain and there have been no case reports of mucoid degeneration of both the ACL and the posterior cruciate ligament (PCL). 2022 Oct 23;34(1):40. doi: 10.1186/s43019-022-00169-9. Lintz F, Pujol N, Boisrenoult P, Bargoin K, Beaufils P, Dejour D. Knee Surg Sports Traumatol Arthrosc. This series describes the clinicoradiological presentation of patients with mucoid ACL, partial arthroscopic debridement of ACL and outcomes. Anterior Cruciate Ligament, is an important structure of the knee joint. Preoperative magnetic resonance imaging (MRI), Fig. have described the following MRI criteria [4]: (1) high signal intensity in the T1 and T2 sequences, (2) increased ACL volume and (3) continuous fibres of ACL shown in the T2 sequence. The mean follow up ranged from 13 to 72months. This ligament consists of two fibers, mainly, the anterio-medial and postero-lateral fibers, respectively. Bethesda, MD 20894, Web Policies Mucoid cystic degeneration of the cruciate ligament. Mucoid degeneration of the anterior cruciate ligament. Conclusions. Assessment of Anterior Cruciate Ligament (ACL) Degeneratio Mucosa Treatment Conclusions Our study provides further evidence that arthroscopic total or partial excision of anterior cruciate ligament is a safe and effective treatment for mucoid degeneration of the anterior . 2013;15(1). Careers. The minimum follow-up was 3 years. Arthroscopic debridement may help relieve the anterior knee pain. Pre-debridement arthroscopic view showing yellowish content in the anterior cruciate ligament. Anterior cruciate ligament mucoid degeneration - Radiopaedia Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. Arthroscopically ACL is intact but fibrillated, yellowish and hypertrophied,with interspersed yellowish mucinous material along the fibers, lack of synovial linning of the ACL. Online ahead of print. -osis is a suffix denoting a process, condition, or state, the histology of the Achilles tendon and in ACL injuries(24-26). We herein describe a case of PCL mucoid degeneration presented with secondary ACL . Methods: Joshita Poojary - Sports Physical Therapist - Padmanabhan's - Linkedin The ligament is mainly responsible for restraining anterior translation of knee. Partial/Total ACL resection arthroscopically- There is marked improvement in the range and reduced posterior pain, but at the cost of increased post-operative knee laxity. Treatment for MDACL usually starts non-surgically with anti-inflammatory drugs and physiotherapy. In the nine included studies, four different scores were used for outcome assessment. Read more, Physiopedia 2023 | Physiopedia is a registered charity in the UK, no. MeSH Coronal proton density-weighted magnetic resonance imaging shows a thickening of the anterior cruciate ligament. This bicentric, retrospective cohort study with an average follow-up of 6years involved 27 patients (29 knees) presenting with symptomatic ACL mucoid degeneration validated by magnetic resonance imaging (MRI). Introduction: Mucoid degeneration of the anterior cruciate ligament (ACL) is a little-known entity. On physical exam, the Lachman test for ACL instability is negative with an ACL ganglion. Ever since mucoid degeneration of the anterior cruciate ligament (MD-ACL) was named by Kumar et al. Terms and Conditions, 8600 Rockville Pike Mucoid change or mucoid degeneration refers to the irreversible tissue degeneration due to the accumulation of mucin within the fibers of tendons, ligaments, and fibrocartilage. Would you like email updates of new search results? Keywords used for the Search were mucoid degeneration, anterior cruciate ligament and ACL. Preoperative and postoperative KOOS questionnaires were compared and showed improvement in all categories. Skeletal Radiol. Mucoid degeneration (MD) of the anterior cruciate ligament (ACL) is a rare pathological entity that has been found in patients with pain and limited range of motion of the knee in association with a bulky ACL shown on magnetic resonance imaging (MRI). Therefore, Anterior Cruciate Ligament tear is more susceptible during any injury to the knee. Several critical distinctions allow a confident diagnosis of an ACL ganglion cyst. All patients (100%, n=11) reported an improvement in pain. The aetiology of MDACL is not clearly understood. ACL mucoid degeneration is present on ~10% (range 9-12%) of 3 T MRI examinations and 2% of 1.5 T MRI examinations 6. 2013 Jun 20;15:59. doi: 10.11604/pamj.2013.15.59.2534. Two patients uderwent secondary ligamentoplasty. Clin Orthop Surg. Preoperative magnetic resonance imaging (MRI) scan. Clipboard, Search History, and several other advanced features are temporarily unavailable. 2007;90(3):1923. 2022 Apr 11;31:67-71. doi: 10.1016/j.jor.2022.04.004. The extracted data were assessed for meta-analysis. https://doi.org/10.1016/j.arthro.2008.02.004, Morice A, Coupry A, Lintz F, Robert H (2013) Reduction plasty for hypertrophic anterior cruciate ligament mucoid degeneration: clinical and knee laxity outcomes in 23 cases. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Bookshelf There was a high rate of association between degenerative lesions and MDACL, ranging from 39 to 96%. Preoperative assessment included a questionnaire, clinical examination (Lachman and pivot shift tests), MRI and standard radiography. Conditions that resembles the clinical findings are: Get Top Tips Tuesday and The Latest Physiopedia updates, The content on or accessible through Physiopedia is for informational purposes only. Introduction Mucoid degeneration of the anterior cruciate ligament (ACL) is a little-known pathology. Mucoid degeneration, is the irreversible degeneration of the tissue with the infiltration of mucin(glycosaminoglycans) within the fibers[1][2]. National Library of Medicine National Library of Medicine Its interstitial nature within the ACL structure contrasts with synovial cyst of the ACL. Deep Seated Pain at Back of Knee with Bending | Dr HC Chang 1992;159(2):35760. MM and A performed the literature search, and data analysis. Rajani AM, Shah UA, Mittal ARS, Gupta S, Garg R, Punamiya M. Knee Surg Relat Res. The .gov means its official. A 48-year-old-male patient presented with knee pain and limitation of motion. ACL Mucoid Degeneration in Knee - Diagnosis & Treatment | Dr. Hemendra This was lowest in the study of Cha et al. Signal intensity of the anteromedial bundle (AMB) or posterolateral bundle (PLB) graft standardized to the intensity of the PCL was defined as signal intensity ratio (SIR). (PDF) Assessment of imaging, pathoanatomy and - Academia.edu Its function is to stabilize the knee while bending and rotating; the ACL also keeps the knee from shifting out of place or moving anteriorly (toward the front) with pivoting activities. For treatment of this, partial removing of bulky ACL is generally done, which causes weakness of the ACL. Not really known: Mucoid degeneration of the ACL is seen most commonly in adults (35-55 years of age). Furthermore, this raises the question as to whether the symptoms (pain and diminished range of movement) were solely due to MDACL and not secondary to other associated pathological conditions. What causes mucoid degeneration of ACL? 2010 Jun 1;96(4):400-6. 2009. proposed reduction plasty, which is reduction of the ACL to normal volume without excision of all mucoid tissue. This may support the theory that it is a degenerative process. We report a case of mucoid degeneration of the anterior cruciate ligament (ACL). Correlations between degree of knee instability and SIR were assessed for each bundle, each time point, and each sequence. 2004;182 (5): 1283-7. 1999;81(2):304305. Tamer Sweed. Mucoid change | Radiology Reference Article | Radiopaedia.org Mucoid degeneration (MD) of the anterior cruciate ligament (ACL) is a benign knee pathology, which is often indicated for surgical treatment if symptomatic. Epub 2018 Aug 22. just over two decades ago [], the interest in this condition has quickly gathered pace in the orthopaedic community.Little is known about this condition that affects 1.8-5.3% of the population as per magnetic resonance imaging (MRI) diagnosis [2, 3]. Epub 2021 Nov 24. An official website of the United States government. Mucoid degeneration of the anterior cruciate ligament (ACL) is regarded as a degenerative change in the ligament, which is clinically presented with pain on full extension or flexion in the middle-aged population. Google Scholar, Salvati F, Rossi F, Limbucci N, Pistoia ML, Barile A, Masciocchi C (2008) Mucoid metaplastic-degeneration of anterior cruciate ligament. Roberts CC, Towers JD, Spangehl MJ et-al. sharing sensitive information, make sure youre on a federal Anterior cruciate ligament mucoid degeneration: selecting the best Chudasama CH, Chudasama VC, Prabhakar MM. It results in postoperative laxity, but rarely in frank instability. ANZ J Surg 73(9):712716. Coronal proton density-weighted magnetic resonance, Coronal proton density-weighted magnetic resonance imaging shows a thickening of the anterior cruciate, Sagittal proton density-weighted magnetic resonance, Sagittal proton density-weighted magnetic resonance image shows ill-defined anterior cruciate ligament with increased, Coronal T2 weighted fat suppressed fast spin echo image showed complex anterior cruciate, Pre-debridement arthroscopic view showing yellowish. Post-debridement arthroscopic view showing yellowish, Post-debridement arthroscopic view showing yellowish lesion of the anterior cruciate ligament which was, MeSH At the time the article was created Frank Gaillard had no recorded disclosures. Clipboard, Search History, and several other advanced features are temporarily unavailable. Mucinous material within the substance of ACL produces pain and limited motion in the knee. This study concerns complete ACL resec The site is secure. 2006;69(9):44952. 2022 Nov 24. doi: 10.1007/s00402-022-04659-z. Eight studies showed postoperative improvement in range of motion, whereas Khanna et al. https://doi.org/10.1016/j.jclinepi.2009.06.005. Would you like email updates of new search results? Mucoid degeneration of the anterior cruciate ligament. It has recently been postulated that mucoid degeneration of the ACL is related to the medial knee compartment joint space loss in patients with osteoarthritis or in the OA risk group 6. Arthroscopy. GG and AM interpreted the results and reviewed the manuscript. First, our literature search revealed a heterogeneous group of studies dominated by case reports and case series, with no randomised controlled trials. Arthroscopic findings. 2013 Oct;99(6):693-7. doi: 10.1016/j.otsr.2013.04.010. Background: Mucoid degeneration of the anterior cruciate ligament (ACL) is an uncommon non-traumatic cause of knee pain and motion restriction, typically seen in a middle-aged population. Kwee RM, Hafezi-Nejad N, Roemer FW, Zikria BA, Hunter DJ, Guermazi A, Demehri S. Association of Mucoid Degeneration of the Anterior Cruciate Ligament at MR Imaging with Medial Tibiofemoral Osteoarthritis Progression at Radiography: Data from the Osteoarthritis Initiative. Radiology. Outcome of Arthroscopic Treatment of Mucoid Degeneration of the Mucoid degeneration itself is described as a yellow or brown substance which can be either seen through the most anterior fibers of the ACL or found by probing between them [ 19, 35] (Fig. Unauthorized use of these marks is strictly prohibited. Resnick D, Kransdorf MJ. 2011. Association between magnetic resonance imaging characteristics and pathological findings in entire posterior cruciate ligament with mucoid degeneration. Kim TH, Lee DH, Lee SH, Kim JM, Kim CW, Bin SI. Rehabilitation, orthophony, crenotherapy. Google Scholar, Cha JR, Lee CC, Cho SD, Youm YS, Jung KH (2013) Symptomatic mucoid degeneration of the anterior cruciate ligament. IV (retrospective cohort study). The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Sweed, T., Mussa, M., El-Bakoury, A. et al. Mucoid degeneration,: like degenerative arthritis of a joint, generally occurs as a results of aging. Lintz F, Pujol N, Dejour D, Boisrenoult P, Beaufils P. Orthop Traumatol Surg Res. A total of nine studies were eligible for review. 2010 Jun;96(4):400-6. doi: 10.1016/j.otsr.2010.02.008. Most authors believe that partial ACL resection is the treatment of choice in symptomatic MD of the ACL. Sasaki R, Nagashima M, Takeshima K, Otani T, Okada Y, Aida S, Ishii K. J Int Med Res. 1. Quadriceps and hamstring weakness are common features of people with symptomatic degenerative meniscal tears Surgery may address the structural injury, but . There was strong association between degenerative changes and MDACL (82% having chondral and 69% meniscal lesions), which might suggest that MDACL is a degenerative process. Mucoid degeneration of both ACL and PCL - PubMed sharing sensitive information, make sure youre on a federal "Traumatic theory - post injury, ACL fibroblasts secrete glycosaminoglycans, the mucin substance within the ACL. in 1999 [ 1 ]. We report a case of a patient with mucoid degeneration of the ACL, presenting with posterior knee pain and no history of a major knee trauma. Mucoid degeneration (MD) of the anterior cruciate ligament (ACL) is a benign knee pathology, which is often indicated for surgical treatment if symptomatic. Anterior cruciate ligament ganglia and mucoid degeneration: Coexistence and clinical correlation. -, Hodler J, Haghighi P, Trudell D, Resnick D. The cruciate ligaments of the knee: Correlation between MR appearance and gross and histologic findings in cadaveric specimens. 2009 Jul;17(7):737-40. doi: 10.1007/s00167-008-0690-z. Mucoid degeneration of ACL is a disease affecting ACL in which mucoid like substance (glycosaminoglycans) gets interspersed within the substance of ACL and as a result ACL gets thickened. report that one patient had ACL reconstruction simultaneously after the ACL debridement. Seventeen females (67%) and eight males (33%) were included in the final analysis. Mucoid degeneration of the anterior cruciate ligament (ACL) of the knee can cause knee pain and other symptoms. 2018. http://journals.sagepub.com/doi/10.1177/2325967118786930, Pandey V, Suman C, Sharma S, Rao SP, Kiran Acharya K, Sambaji C (2014) Mucoid degeneration of the anterior cruciate ligament: management and outcome. TS designed the project, literature search and wrote the manuscript. Fourteen knees (48%) had limited flexion, on average 97 degrees. Later studies reported that changes consist of mucoid Results degeneration, neovascularisation, and tendon sheath hyper- Nineteen patients met the inclusion criteria and were inclu- trophy. This is a rare pathological condition, in which, there is increased signal from within the ligament. Hamal B, Karmacharya M, Mangal Joshi K, Gorkhali R. J Nepal Health Res Counc. Initially, partial weightbearing is allowed. Mucoid degeneration of the anterior cruciate ligament. Symptomatic instability was highest in the study of Lintz et al. 2011. Physiotherapy. Arthroscopic debridement of the mucoid degeneration of the ACL was safe and effective in the patient. Diffuse Intrasubstance Signal Abnormalities Ofthe Posterior Cruciate Anterior cruciate ligament ganglia and mucoid degeneration: coexistence and clinical correlation. Keywords: mucoid degeneration, anterior cruciate ligament, acl reconstruction, arthroscopy, knee There was more than 20% loss to follow up in the study of Kim et al., while the three prospective studies had no loss to follow up [13, 14, 18]. Please enable it to take advantage of the complete set of features! Ligaments are very tough, fibrous tissue structures. Mucoid degeneration (MD) of the anterior cruciate ligament (ACL) is a rare pathological entity with disputed theories of origin. The mean age at the time of surgery was 57 years (range, 31 to 78 years). [17] do not mention whether any patients underwent biopsy (Table 3). Disclaimer. CONFLICT OF INTEREST: No potential conflict of interest relevant to this article was reported. The anterior cruciate ligament (ACL) is an important ligament in the knee. You can read more if you want. 2007;245 (3): 916-7. No treatment is usually required. Only nine studies met our inclusion criteria and they were all case series. CAS Mucoid degeneration of the anterior cruciate ligament. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2009 checklist [9]. Arch Orthop Trauma Surg. Results: Accessibility 2022 Nov 24. doi: 10.1007/s00402-022-04659-z. https://doi.org/10.1016/j.jajs.2015.12.001, Ventura D, Nuez JH, Joshi-Jubert N, Castellet E, Minguell J (2018) Outcome of arthroscopic treatment of mucoid degeneration of the anterior cruciate ligament. statement and Online ahead of print. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. Noninfiltrating synovial cysts of the ACL were excluded. Case report: intra-tendinous ganglion of the anterior cruciate ligament Association between magnetic resonance imaging characteristics and pathological findings in entire posterior cruciate ligament with mucoid degeneration. At the time the article was last revised Dai Roberts had no recorded disclosures. 1173185. Arthroscopic treatment may include ACL resection, which raises the questions about the harmlessness of this procedure and the risk of anterior instability. Unable to load your collection due to an error, Unable to load your delegates due to an error. Hide glossary Glossary. 3. A positive Lachman test and a negative pivot shift were noted after surgery in all cases. Read More Created for people with ongoing healthcare needs but benefits everyone. Google Scholar, Chudasama CH, Chudasama VC, Prabhakar MM (2012) Arthroscopic management of mucoid degeneration of anterior cruciate ligament. 1. Mucoid degeneration of both ACL and PCL. Patients with symptomatic MDACL commonly present with posterior knee pain and limitation of knee flexion or extension [2, 6].

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